Remi V. Klotz, PhD

Assistant Professor of Research
rklotz@som.umaryland.edu

Research

As a postdoctoral research fellow in Dr. Min Yu’s group at the University of  Southern California, Remi demonstrated that circulating tumor cells  (CTCs) derived and expanded ex vivo from patients recapitulate human metastatic disease in an animal model. His work contributed to a better understanding of how some CTCs cross the blood-brain barrier and establish tumors in the brain. Later on, Remi joined Dr. Yu’s lab at the University of Maryland School of Medicine as a non-tenure track faculty member in the Department of Pharmacology. Applying an integrated approach using single-cell multi-omics analysis, computational biology, microfluidic technologies, patient samples, in-vivo models, and CRISPR screens, Remi is currently investigating early brain colonization of disseminated cancer cells and the microenvironmental regulation of brain metastasis.

Education

• 2005-2008 B.S., Cellular Biology, University of Lorraine, France
• 2008-2010 Master, Biology and Health, University of Lorraine, France
• 2010-2014 Ph.D., Cancer Biology, University of Lorraine, France
• Thesis Advisor: Phillipe Becuwe and Stéphanie Grandemange
  Title: Role of Damaged DNA Binding 2 protein in the response of breast
  tumor cells to therapeutic agents

Hobbies

While Remi explores the intricate field of circulating tumor cells, he also finds joy in baking. Despite seeming unrelated, his fascination with geopolitics, finance, and reality TV shows provides an intriguing insight into his diverse interests. For him, deciphering global events and analyzing the extravagant drama of the Real Housewives on Bravo presents a strangely captivating duality.